Monday, September 11 | 8:15 – 11:15 pm | Bills at New York Jets
Sunday, September 17 | 1 – 4 pm | Las Vegas Raiders at Bills
Sunday, September 24 | 1 – 4 pm | Bills at Washington Commanders
Sunday, October 1 | 1 – 4 pm | Miami Dolphins at Bills
Sunday, October 8 | 9:30 am – 12:30 pm | Jacksonville Jaguars at Bills (in London)
Sunday, October 15 | 8:20 – 11:20 pm | New York Giants at Bills
Sunday, October 22 | 1 – 4 pm | Bills at New England Patriots
Thursday, October 26 | 8:15 – 11:15 pm | Tampa Bay Buccaneers at Bills
Sunday, November 5 | 8:20 – 11:20 pm | Bills at Cincinnati Bengals
Monday, November 13 | 8:15 – 11:15 pm | Denver Broncos at Bills
Sunday, November 19 | 4:25 – 7:25 pm | New York Jets at Bills
Sunday, November 26 | 4:25 – 7:25 pm | Bills at Philadelphia Eagles
Sunday, December 10 | 4:25 – 7:25 pm | Bills at Kansas City Chiefs
Sunday, December 17 | 4:25 – 7:25 pm | Dallas Cowboys at Bills
Saturday, December 23 | 8 – 11 pm | Bills at Los Angeles Chargers
Sunday, December 31 | 1 – 4 pm | New England Patriots at Bills
Week 18 – TBD – Bills at Miami Dolphins